#Hemoglobin a1c normal range male trial
During the last decade, guidelines implemented HbA1c as equal diagnostic criterion besides measurement of plasma glucose for the diagnosis of diabetes as long as the HbA1c method is certified by the National Glycohemoglobin Standardization Program (NGSP) and is traceable to the Diabetes Control and Complications Trial (DCCT) reference assay. In daily practice, the advantages of HbA1c include less day to day variability during acute illness and greater convenience as fasting is not required compared to fasting plasma glucose measurements and oral glucose tolerance tests. Implementation of them into daily practice may improve patient care and diagnosis of diabetes and reduce the risk of misdiagnosis and subsequent overtreatment of diabetes in elderly patients.ĭetermination of glycated hemoglobin (HbA1c) is given a central role in the monitoring of antihyperglycemic therapy. As a consequence age-dependent reference values for HbA1c were derived from two large and well defined reference populations. The present study confirmed the previously observed increase of HbA1c with increasing age in non-diabetic individuals. Linear regression analyses confirmed the positive associations of HbA1c with age which was independent of BMI Conclusion ANOVA revealed up to 8.5 mmol/Mol (0.77%) or 7.3 mmol/Mol (0.68%) higher estimated mean levels of HbA1c in the oldest compared to the youngest age group in SHIP-0 or SHIP-trend, respectively. In both study populations an increase in HbA1c with age was observed. For people aged ≥60 years the URL was 47.5 mmol/Mol (6.5%). Reference intervals were derived from a healthy subpopulation with the upper reference limit (URL) for HbA1c of 42.1 mmol/Mol (6.0%) for individuals aged 20–39 years increasing to 43.2 mmol/Mol (6.1%) for individuals aged 40–59 years. Reference intervals for HbA1c were determined. Multivariable linear regression models were performed. HbA1c was determined by means of high-performance liquid chromatography. Methodsįour thousand two hundred sixty three participants from the Study of Health in Pomerania (SHIP-0) and 4402 participants from the independent study SHIP-Trend were included. The present study aimed to evaluate HbA1c levels in relation to age in two independent population-based cohorts and to derive age-specific reference intervals. However, this observation did not reach incorporation into daily clinical practice or the respective guidelines. Several studies report increased levels of HbA1c in nondiabetic elderly. Measurement of gylcated hemoglobin A1c (HbA1c) plays a central role in monitoring quality of antidiabetic therapy and in the diagnosis of diabetes.
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